J Parasitol. 2008 Oct 6:1. [Epub ahead of print]
Inhibition of Toxoplasma gondii and Plasmodium falciparum infections in vitro by NSC3852, a redox active anti-proliferative and tumor cell differentiation agent
Strobl JS, Seibert CW, Li Y, Nagarkatti R, Mitchell SM, Rosypal AC, Rathore D, Lindsay DS.
We searched the National Cancer Institute (NCI) compound library for structures related to the anti-tumor quinoline NSC3852 (5-nitroso-8-quinolinol) and used a computer algorithm to predict the anti-protozoan activity of each of 13 structures. Half of these compounds inhibited T. gondii tachyzoite propagation in human fibroblasts at
PMID: 18837587 [PubMed - as supplied by publisher]
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